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Her-2: The Making of Herceptin, a Revolutionary Treatment for Breast Cancer (English Edition) Kindle电子书

平均 4.0 星 1 条商品评论
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图书描述

2011年4月27日 1
Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free.

        Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers.

        Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

基本信息

  • 版本: Kindle电子书
  • 文件大小: 478 KB
  • 纸书页数: 240
  • 出版社: Random House; 1 (2011年4月27日)
  • 语种: 英语
  • ASIN: B004JHYRPE
  • 标准语音朗读: 已启用
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  • 用户评分: 平均 4.0 星 1 条商品评论
  • 亚马逊热销商品排名: Kindle商店商品里排第50,297名 (查看Kindle商店商品销售排行榜)
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4.0 颗星,最多 5 颗星

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2013年8月28日
版本: 平装已确认购买

此商品在美国亚马逊上最有用的商品评论

美国亚马逊: 4.6 颗星,最多 5 颗星 50 条评论
Marily
5.0 颗星,最多 5 颗星Amazing Miracle, Thank you Dr Slamon!
2016年11月4日 - 已在美国亚马逊上发表
已确认购买
5 个人发现此评论有用.
Top Cat
4.0 颗星,最多 5 颗星Good, but dated.
2014年12月24日 - 已在美国亚马逊上发表
版本: 平装已确认购买
2 个人发现此评论有用.